Objective To analyze the application effect of a risk stratification based tiered rehabilitation intervention program in sepsis-induced coagulopathy (SIC) diseases. Methods A retrospective analysis was conducted on the data of SIC patients admitted to Hangzhou Xiaoshan Hospital of Traditional Chinese Medicine, from January 2025 to September 2025. After using the 1∶1 propensity score matching (PSM) method to balance baseline characteristics such as age, gender, source of infection, underlying diseases, and initial condition, 49 patients who received routine intensive care and rehabilitation guidance were selected to be included in the control group, and 49 patients who received stepwise rehabilitation intervention based on the risk stratification of coagulation function status were included in the observation group. The coagulation indexes [prothrombin time (PT), activated partial thromboplastin time (APTT), Ddimer (D-D)], sequential organ failure assessment (SOFA), severity of disease [acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ)], clinical outcome, new major bleeding events and deep vein thrombosis were statistically analyzed and compared between the two groups. Results On the 14th day of intervention, the PT and APTT values of both groups of patients were significantly shorter than those before the intervention in the same group (all P＜0.05). The D-D level, SOFA score, and APACHE Ⅱ score were all significantly lower than those before the intervention in this group (all P＜0.05). Moreover, the above-mentioned indicators in the observation group were significantly lower than those in the control group (all P＜0.05). The intensive care unit (ICU) hospitalization time and total hospitalization time of the observation group were shorter than those of the control group (all P＜0.05). There were no significant differences in the 28 day all-cause mortality rate, major bleeding events, and incidence of new deep vein thrombosis between the two groups (all P＞0.05). Conclusion A tiered rehabilitation intervention based on risk stratification can effectively improve coagulation function in patients with SIC disorders and promote organ function recovery.