Objective To analyze the influence of the interdisciplinary team collaboration nursing model on disease severity and blood gas indicators of children with neonatal respiratory distress syndrome (NRDS). Methods A total of 90 children with NRDS in Zhengzhou Maternal and Child Health Hospital from January 2023 to January 2025 were selected as the research subjects and divided into a basic group and a study group by the random number table meth- od. In the basic group, 45 cases were given conventional nursing intervention, while in the study group, 45 cases were given intervention based on the interdisciplinary team collaboration nursing model. The rehabilitation progress, disease severity, blood gas indicators and incidence of complications of the two groups were compared. Results The duration of respiratory support, hospital stay and recovery time of chest X-ray in the study group were all lower than those in the basic group (P < 0.05). After the intervention, the study group demonstrated signi?cantly lower scores on the Score for Neonatal Acute Physiology II (SNAP-II) and higher scores on the Pediatric Critical Illness Scale (PCIS) compared to the basic group (P < 0.05). After the intervention, the levels of arterial partial pressure of oxygen (PaO2) and blood oxygen saturation (SpO2) in the study group were higher than those in the basic group, while the level of arterial partial pressure of carbon dioxide (PaCO2) was lower than that in the basic group (P < 0.05). The incidence of complications in the study group was lower than that in the basic group (P < 0.05). Conclusion The interdisciplinary team collaboration nursing model can e?ectively alleviate disease severity in children with neonatal respiratory distress syndrome, improve oxygen- ation function, reduce the incidence of complications, and accelerate the progress of rehabilitation.