Objective To investigate the effects of a parent-accompaniment postoperative emotional regulation assistance combined with voice intervention on emergence agitation, hemodynamics, and stress state during the recovery period in children under general anesthesia. Methods A total of 89 children under general anesthesia who underwent surgical treatment in Xuchang Hospital of Traditional Chinese Medicine from July 2021 to September 2024 were selected as the research subjects and divided into group A（ n=45） and group B（ n=44） according to the random number table method. The 44 cases in group B received conventional intervention, and the 45 cases in group A received emotional regulation and voice intervention from their parents on the basis of group B. The two groups were compared in terms of agitation during the recovery period [pediatrie anaesthesia emergence delirium (PAED) score, Steward recovery score (SRS)], hemodynamics (blood pressure, heart rate), stress state (norepinephrine, epinephrine), recovery quality (anesthesia emergence time, respiratory recovery time, eye opening time, language autonomous expression time) and the incidence of adverse events during the anesthesia recovery period. Results Group A showed significantly lower PAED scores, shorter agitation duration, and higher SRS than group B (all P<0.05). Mean blood pressure and heart rate were lower in group A than in group B (P<0.05). Postoperative levels of norepinephrine and epinephrine were significantly reduced in group A (P<0.05). The anesthesia emergence time [(15.97±4.31) min], respiratory recovery time [(3.14±0.87) min], eye opening time [(11.87±2.01) min], and autonomous language expression time [(21.64±2.58) min] in group A were all shorter than those in group B [(20.21±6.67) min, (4.21±1.02) min, (14.87±1.58) min, (29.68±7.36) min, respectively] (all P<0.05). The total incidence of adverse events (nausea/vomiting, respiratory obstruction, severe cough, laryngospasm) in group A (4.44%) was significantly lower than that in group B (20.45%, P <0.05). Conclusion A postoperative emotional regulation assistance with voice intervention for pediatric patients undergoing general anesthesia surgery who receive parental accompaniment improves hemodynamics, recovery quality, and duration of agitation by attenuating the release of stressors, and reduces the incidence of adverse events during emergencing from anesthesia. This study provides a reference for optimizing the quality of postoperative recovery in children undergoing general anesthesia, and the program has potential application prospects in intelligent nursing.