Objective To address the challenges of fragmented and heterogeneous information systems in multi-campus hospitals by constructing an integrated smart hospital system aimed at improving medical quality and management efficiency. Methods An integrated framework combining an online diagnosis and treatment platform with an offline intelligent operation center was established to enable synergy between technology and management. Construction focused on three dimensions as medical care, services, and administration across four aspects of quality, efficiency, safety, and patient experience. Results After 22 months of stable operation, the number of physical examination visits increased by 45% in 2023. Patient satisfaction with informatization rose by 17.9%, and consumable expenses decreased by 3.4%. Conclusion The smart hospital model enabled homogeneous services, intelligent management, and refined operations across multiple campuses, significantly improving patient experience and promoting high-quality hospital development.