Objective To investigate the effect of a patient-participatory poly-silicone foam dressing intervention programme on pressure injury and inflammatory factor levels in fracture patients. Methods 86 cases of fracture patients admitted to Department of Orthopedics, Shangqiu Central Hospital from March 2022 to September 2024 were selected and randomly divided into the control group (n=43, receiving the routine nursing care) and the observation group (n=43, on the basis of the routine nursing care, the patient participated in the foam dressing intervention scheme) . The pressure injuries, inflammatory factor levels, wound healing and comfort level of the two groups were compared. Results Before intervention, there was no significant difference (P >0.05) in the scores of the Bates Jensen wound assessment tool (BWAT), wound area, General Comfort Questionnaire (GCQ), C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) between the two groups. After intervention, the BWAT score[(14.09 ±1.02 )vs(15.45 ±1.13)] and the average levels of CRP[(15.09 ±2.02)vs(18.45 ±2.73)], IL-6[(30.33 ±2.61) vs(37.46±2.75)], IL-8[(38.54±5.99)vs(42.65±5.87)], and TNF-α[(18.55±3.64)vs(22.75±3.82)] in the observation group were lower than those in the control group (P<0.05). The wound area[(1.33±0.11)vs(1.40 ±0.15)]was smaller than that of the control group (P <0.05). The wound healing rate[(75.63 ±8.24)vs(72.07 ±7.08)]is higher than that of the control group (P<0.05). The GCQ score was higher than that of the control group (P<0.05), and the incidence rate of pressure injuries (4.65%vs18.60%) was lower than that of the control group (P <0.05). Conclusion The patient-participatory poly-silicone foam dressing intervention programme can effectively prevent pressure injuries in fracture patients, reduce the levels of inflammatory factors, promote wound healing, and improve patients’ comfort.