Objective To investigate the effects of 5A continuous intervention mode on self-management ability and vascular endothelial function in patients with hypertension comorbid type 2 diabetes. Methods A total of 86 patients with hypertension comorbid type 2 diabetes from November 2022 to July 2024 in Fuwai Central China Cardiovascular Hospital were selected and divided into two groups, which are the control group and the observation group (both n=43) by random number table method. The control group received routine intervention, and the observation group was given 5A continuous intervention, and the self-management ability, vascular endothelial function, blood sugar and blood pressure control levels of the two groups were compared. Results After intervention, the score of the Adult Health Self-management Scale Rating System (AHSMSRS) in the observation group was higher than that in the control group (P < 0.05). After intervention, diastolic blood pressure (DBP), systolic blood pressure (SBP) and fasting blood glucose (FBG) levels in the observation group were lower than those in the control group (P < 0.05). After intervention, the levels of angiotensin Ⅱ (Ang-Ⅱ) and vascular endothelial growth factor (VEGF) in the observation group were lower than those in the control group (P < 0.05). Conclusion 5A continuous intervention mode can effectively improve selfmanagement ability, enhance blood sugar and blood pressure control levels, and improve vascular endothelial function in patients with hypertension comorbid type 2 diabetes.