【Abstract】 Objective To explore the impact of nursing interventions based on the concept of enhanced recovery after surgery (ERAS) on the recovery effect of patients undergoing enterostomy, and provide scientific basis for optimizing nursing models. Method Eighty patients who underwent undergoing enterostomy at Xinyi People’s Hospital from January 2022 to December 2024 were selected and randomly divided into an observation group (ERAS based nursing intervention) and a control group (conventional nursing), with 40 patients in each group. The postoperative recovery time, incidence of complications, patient satisfaction, and quality of life scores were compared between the two groups. Results The results showed that the postoperative recovery time was significantly shortened (P ＜ 0.05), and the incidence of complications was significantly reduced (P ＜ 0.05) in the observation group, and the quality of life scores and patient satisfaction in the observation group were higher than those of the control group (P ＜ 0.05). Conclusion Nursing interventions based on the ERAS concept can significantly promote functional recovery, improve quality of life and nursing satisfaction in patients undergoing enterostomy, and are worthy of significant clinical promotion.