【Abstract】 Objective To investigate the clinical effect of Tianshu Tablets in treating acute attacks of migraine without aura and compare it with Flunarizine Hydrochloride Tablets, evaluating both short-term and long-term efficacy. Methods A total of 120 patients with acute attacks of migraine without aura were selected and randomly divided into the observation group (60 cases) and the control group (60 cases). The observation group was treated with Tianshu Tablets alone, while the control group received Flunarizine Hydrochloride Tablets. The treatment lasted for two weeks, with a 12- week follow-up.The pain relief effect during the acute phase and long-term efficacy (including headache recurrence rate, headache intensity, and frequency control) were assessed in both groups . Results There was no significant difference in pain relief during the acute phase between the two groups(P ＞ 0.05). However, regarding long-term efficacy, the observation group (Tianshu Tablets) showed significant advantages, including a significantly lower headache recurrence rate, reduced headache frequency, and more notable relief in headache intensity(P ＜ 0.05). Conclusion Tianshu Tablets are as effective as Flunarizine Hydrochloride Tablets in treating acute attacks of migraine without aura, but they demonstrate more significant long-term efficacy, suggesting their potential for clinical application and promotion.