【Abstract】 Objective To explore the effects of the CICARE communication model on the psychological state, compliance, and coping styles of uremic hemodialysis patients. Methods A total of 104 uremic hemodialysis patients were randomly divided into an observation group and a control group, with 52 cases in each group. The control group received routine care, while the observation group received the CICARE communication model in addition to routine care. The intervention lasted for 12 weeks. Patients’ psychological state (measured by SAS, SDS, and SPB scales), dialysis compliance, and coping styles (measured by MCMQ) were assessed before and 3 months after the intervention. Results ① Psychological State: After the intervention, the observation group had significantly lower scores in anxiety [(43.26±5.99) vs [(48.87±6.78)], depression [(42.36±5.88) vs (50.74±7.03)], and self-perceived burden [(32.23±3.47) vs (37.66±3.21)] compared to the control group (P ＜ 0.05). ② Dialysis compliance: Post-intervention, the observation group had significantly higher scores in medication adherence, diet, dialysis regimen, and fluid intake compared to the control group (P ＜ 0.05). The overall compliance score [(96.37±13.37) vs (91.16±12.65)] also improved significantly (P ＜ 0.05). ③ Coping Styles: After the intervention, the observation group scored significantly higher in confrontation [(24.06±3.32) vs (20.85±2.88)] and significantly lower in avoidance [(8.42±1.15) vs (11.25±1.54)] and resignation [(6.03±1.04) vs (6.85±1.13)] compared to the control group (P ＜ 0.05). Conclusion The CICARE communication model effectively improves the psychological state of uremic hemodialysis patients, enhances treatment compliance, and promotes the development of positive coping styles. It is recommended for broader clinical application.