Since 2010, with the first transcatheter aortic valve replacement (TAVR) in China performed in the Department of Cardiology, Zhongshan Hospital Affiliated to Fudan University, the field of heart valve intervention has developed rapidly, and a number of interventional valves have been approved by NMPA. Cobalt-chromium alloy is the main raw material of balloon-expandable valves stents. From the perspective of clinical application, in order to improve the fatigue durability of cobalt-chromium alloy valve stents after implantation in the human body during the contraction and relaxation of the heart, this study explores the changing trend of tensile strength, fracture elongation, radial support, retraction, hardness and microtissue under different vacuum heat treatment conditions. The experimental results show that the excellent performance of cobalt-chromium alloy valve stents can be obtained when the vacuum heat treatment temperature is 1000℃ and the holding time is 20minutes. This study aims to evaluate and analyze the vacuum heat treatment of stents, providing a theoretical basis for the development and application of balloon-expandable cobaltchromium alloy valves stents, and offering references for future research on interventional valves.