Objective To study the effects of team intervention based on stress system model on disease perception, self-efficacy and health behavior of lung cancer patients undergoing radiotherapy. Methods 90 patients with lung cancer receiving radiotherapy in the First Affiliated Hospital of Zhenzhou Uiversity from February 2022 to February 2024 were randomly assigned. 45 patients in the control group received conventional intervention, and 45 patients in the observation group received team intervention based on stress system model. The disease perception, psychological stress state, self-efficacy and health behavior of the two groups were compared. Results The score of Brief Illness Perception Questionnaire (BIPQ) in observation group was lower than that in control group (P < 0.05). The post-intervention stress response questionnaire (SRQ) score of the observation group was lower than that of the control group (P < 0.05). The scores of general self-efficacy scale (GSES) and Health Promotion Lifestyle Scale-Ⅱ(HPLP-Ⅱ) in the observation group were higher than those in the control group (P < 0.05). Conclusion The team intervention based on the stress system model can effectively improve the self-efficacy, improve the disease perception, reduce the psychological stress state, and promote the development of health behaviors in patients with lung cancer radiotherapy.