Objective To investigate the epidemic situation of influenza cases in a sentinel hospital in Pingdingshan City from 2021 to 2022, to grasp the local influenza characteristics in Pingdingshan City, and to provide reference for influenza prevention and control. Methods Influenza cases and etiology characteristics reported from fever clinic of a sentinel hospital in Pingdingshan City from 2021 to 2022 were collected and the pathogenic characteristics of influenza virus and prevalence trend were analyzed. Results From 2021 to 2022, the proportion of influenza-like illness (ILI) in the total number of outpatient, emergency medicine and pediatric visits fluctuated between 0.09% and 2.15%. Influenza-like cases were mainly concentrated in the 43rd week of 2021 to the 2nd week of 2022, with the largest number of cases in the age group below 5 years old, totaling 2185 cases, accounting for 61.74% of the total number of cases. Among 686 influenza-like cases, 181 nucleic acid positive specimens were detected, all of which were B-type victoria. 110 strains were isolated, including 73 chicken embryo strains and 37 cell strains. Conclusion The age of influenza in a sentinel hospital in Pingdingshan City was concentrated in children under 5 years old, and the epidemic virus was mainly B-type victoria.