Objective To investigate the cowelation between the changes of D-Dimer (D-D), Fibrinogen (Fib), Activated partial thromboplastin time (APTT) in patients with coronary heart disease (CHD) and the occurrence of cardiovascular events. Methods A total of 92 CHD patients received in Zhoukou Hospital of TCM from September 2021 to December 2023 underwent Percutaneous Coronary Intervention(PCI). The patients after PCI were treated as the observation group, and 40 healthy subjects were taken as the control group. D-D, Fib, and APTT levels were compared between the two groups. Cardiovascular events in patients were recorded by telephone follow-up within 3 months after PCI, and the correlation between D-D, Fib, APTT and cardiovascular events in CHD patients after PCI was analyzed. Results APTT levels in the observation group were lower than those in the control group, while D-D and FIB levels were higher than those in the control group. Patients with cardiovascular events had higher D-D and FIB levels than those without cardiovascular events, while APTT levels in patients without cardiovascular events were lower than those in patients with cardiovascular events (P<0.05). According to binary logistic regression analysis, elevated levels of D-D, FIB, and APTT are high-risk factors for postoperative cardiovascular events in CHD patients (P<0.05). Conclusion D-D, Fib, and APTT indicators are involved in the patient’s pathological process and can effectively predict postoperative cardiovascular events in CHD patients, which is worthy of clinical promotion.