Alzheimer’s disease (AD) is a neurode-generative disease and the etiology is highly complex. As the world’s population ages, its incidence is increasing, but the pathogenesis is still unclear. Especially in recent years, COVID-19 has raged around the world, and the infection increases Alzheimer’s risk by more than 50% in elderly people[1]. Objective To systematically summarize the traditional pathogenic hypothesis, the latest research on pathogenic mechanism, and the new drugs and therapeutic methods of AD. Methods To collate the research results of the pathogenesis, various treatment methods including early intervention and treatment outcome of AD, and make the research results into a systematic and comprehensive. Results & Conclusions With the new important findings and achievements in pathogenesis, imaging research and clinical treatment, to address this global problem of AD new ideas and new methods such as RNAi therapy and TRIM11 gene therapy continue to emerge. Innovation It summarizes the latest theories and research methods such as the changes of patients’ choroid plexus, blood diagnosis, gene therapy and cell therapy, and it provides more theoretical reference for AD research.