Objective To study the effectiveness and safety of non-invasive pelvic floor electrical stimulation therapy instruments comparing with invasive ones. Methods The 3D simulation model of the pelvic floor was constructed in COMSOL Multiphysics simulation software, and the frequency and amplitude of the stimulation voltage were changed to simulate the distribution of multiple groups of current density, and the effectiveness and safety were evaluated in combination with in vitro tissue experiments. Results and Conclusion Non-invasive pelvic floor electrical stimulation can achieve the pelvic floor muscle stimulation effect similar to that of invasive pelvic floor electrical stimulation therapy instruments by increasing the amplitude and frequency of the stimulation voltage. Placing wet wipes or applying conductive ointment at the stimulation site can avoid electric burns and improve the stimulation effect. Innovation The effectiveness and safety of non-invasive pelvic floor electrical stimulation therapy instruments are currently lacking research evidence. This study indicates that non-invasive pelvic floor electrical stimulation has potential clinical application prospects and can provide reference for subsequent clinical research.