Outcomes-Based Education (OBE) is a talent cultivation concept that focuses on students’ learning outcomes to develop professional training plans, conduct teaching management and teaching resources allocation. Taking the professional basic course “Ethics in Biomedical Engineering Research” of biomedical engineering major in Shanghai Jiao Tong University as an example, this article analyzes the establishment of learning objectives for a course based on the OBE theory from a teacher’s perspective, achieving support for graduation requirements, and achieving comprehensive evaluation and continuous improvement of the course objectives. Through case analysis of this course, it helps course teachers understand the OBE theory and build courses that meet the OBE theory and engineering education certification requirements.