First class undergraduate education is the substrate for the first-class university, while the talent cultivation system is the key to improving the quality of undergraduate education. As the first ABET-accredited program in mainland China, Shanghai Jiao Tong University’s biomedical engineering substantially redesigned its curriculum and education system based on student outcomes. This article outlines the substantial changes in administration, curriculum, and the student support system of the school of biomedical engineering of Shanghai Jiao Tong University in the aspect of outcome-based education (OBE). In addition, we aim to share our practice and experiences on how to build an OBE-oriented undergraduate engineering program.