Objective To identify risk genes for anxiety disorders. Methods Using the Fine-mapping of causal gene sets, the data from the UK Biobank genome-wide association study on anxiety disorders were integrated with quantitative trait locus data from a large sample of human brain expression to find risk genes associated with anxiety disorders. Results and conclusions In this study, 12 genes including FAM167A, MSRA and TDH were screened for the potential risk genes that may lead to anxiety disorders, the correlation between them and anxiety disorders is proved, and it also provides a possible direction for the subsequent development of clinical diagnosis and treatment targets for anxiety disorders.