Objective To analyze the value of early detection of albumin (ALB) in predicting acute kidney injury in patients with acute myocardial infarction (AMI). Methods A total of 100 patients with acute myocardial infarction (AMI) were enrolled, including 48 patients with acute kidney injury and 48 patients without acute kidney injury. The predictive value of early ALB on acute kidney injury in AMI patients was investigated. Results There were no significant differences in gender, age and body mass index (P > 0.05). Patients with renal injury had higher heart rate, systolic blood pressure, diastolic blood pressure, urine volume, white blood cell, blood glucose and serum creatinine, and lower probability of coronary artery stenting, left ventricular ejection fraction, erythrocyte specific volume and ALB levels (P < 0.05). Multivariate logistic regression analysis showed that the risk factors of renal injury included ALB, white blood cell count and serum creatinine (P < 0.05). After adjusting for confounding factors, hypo ALB was a risk factor for renal injury (P < 0.05). Conclusion Early detection of serum ALB level can predict the risk of acute kidney injury in patients with acute myocardial infarction.