Objective By analyzing the monitoring data of suspected abnormal vaccination reactions in Hebei District of Tianjin, it provides a basis for evaluating the operation of AEFI monitoring system, vaccine safety and improving the quality of vaccination work. Methods Establish a database with Excel, and analyze relevant indicators with descriptive epidemiological methods to collect the case data reported by the AEFI monitoring system in Hebei from 2013 to 2020. Results A total of 1 306 cases of AEFI have been reported in Hebei District of Tianjin, with a reported incidence of 106.54/100 000.Among them, there were 932 cases of general reaction (71.36%), 191 cases of abnormal reaction (14.62%), 182 cases of coincidence (13.94%), and 1 case of psychogenic reaction (0.08%). There were no vaccination accidents. A total of 22 cases of severe AEFI were reported, accounting for 1.68% of the total reported cases.The reporting timeliness rate, investigation rate, and investigation timeliness rate are all 100%, and the reporting coverage rate of each street reaches 100%. Conclusions The AEFI monitoring system in Hebei District continued to operate normally, with high sensitivity and reporting quality. In the future, training and guidance of relevant personnel can be carried out regularly to eliminate the negative impact of AEFI, improve the public’s correct awareness of vaccination, and create a good atmosphere for vaccination.