The experimental teaching mode of medical imaging technology based on numerical simulation proposed in this paper starts from the original principle, uses mathematical formulas to express the data acquisition and processing process, and then programs the mathematical formulas, which indicates that the whole imaging process is described by numerical simulation, visualized and can realize real-time interaction. Practice shows that this teaching mode can realize clear, accurate, scientific, and quantitative teaching, and the experimental content be adjusted and designed according to students' learning situation, which enriches the interactivity and autonomy of experimental teaching of medical imaging technology.